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PXDN reduces autophagic flux in insulin-resistant cardiomyocytes via modulating FoxO1.
Li C, Liu Z, Xu Q, Peng H, Cao J, Zhou H, Zhang G, Cheng G, Shi R. Li C, et al. Cell Death Dis. 2021 Apr 26;12(5):418. doi: 10.1038/s41419-021-03699-4. Cell Death Dis. 2021. PMID: 33903591 Free PMC article.
Not consistent with the effects of si-PXDN, double-silence of PXDN and FoxO1 significantly increased cell death, suppressed autophagic flux and declined the level of FoxO1 and PXDN, while the expression of LC3-II was unchanged under PA stimulation. Furthermor …
Not consistent with the effects of si-PXDN, double-silence of PXDN and FoxO1 significantly increased cell death, suppressed au …
Integrated RNA- and miRNA-sequencing analysis identifies molecular basis for stress-induced heart injury in mouse models.
Luo X, Zhou Z, Wu J, Zhang L, Zhang J, Li J. Luo X, et al. Int J Cardiol. 2022 Feb 15;349:115-122. doi: 10.1016/j.ijcard.2021.11.084. Epub 2021 Dec 6. Int J Cardiol. 2022. PMID: 34883141 Free article.
In this study, we aimed to explore the potential pathophysiological mechanisms of stress-induced heart injury in mouse models. METHODS: The RNA- and miRNA- sequencing profiles from five stress-treated mice and five control mice were performed. ...After the validation in vi …
In this study, we aimed to explore the potential pathophysiological mechanisms of stress-induced heart injury in mouse models. METHOD …
CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN.
Zhou L, Zhai G, Tian G. Zhou L, et al. Aging (Albany NY). 2024 Mar 15;16(6):5567-5580. doi: 10.18632/aging.205664. Epub 2024 Mar 15. Aging (Albany NY). 2024. PMID: 38517371 Free PMC article.
Consistently, CRIF1 overexpression also inhibited DOX-induced oxidative stress and senescence in AC16 cells. Moreover, CRIF1 was verified to bind to PXDN and inhibited PXDN expression. The inhibitory effects of CRIF1 overexpression on DOX-induced oxidative stress an …
Consistently, CRIF1 overexpression also inhibited DOX-induced oxidative stress and senescence in AC16 cells. Moreover, CRIF1 was verified to …
Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo.
Elliott BA, Ho HT, Ranganathan SV, Vangaveti S, Ilkayeva O, Abou Assi H, Choi AK, Agris PF, Holley CL. Elliott BA, et al. Nat Commun. 2019 Jul 30;10(1):3401. doi: 10.1038/s41467-019-11375-7. Nat Commun. 2019. PMID: 31363086 Free PMC article.
Specifically, two box C/D snoRNAs (SNORDs) and the 2'-O-methyltransferase fibrillarin lead to Nm modification in the protein-coding region of peroxidasin (Pxdn). The presence of Nm modification increases Pxdn mRNA expression but inhibits its translation, regulating …
Specifically, two box C/D snoRNAs (SNORDs) and the 2'-O-methyltransferase fibrillarin lead to Nm modification in the protein-coding region o …
Peroxidasin-like protein: a novel peroxidase homologue in the human heart.
Péterfi Z, Tóth ZE, Kovács HA, Lázár E, Sum A, Donkó A, Sirokmány G, Shah AM, Geiszt M. Péterfi Z, et al. Cardiovasc Res. 2014 Mar 1;101(3):393-9. doi: 10.1093/cvr/cvt256. Epub 2013 Nov 18. Cardiovasc Res. 2014. PMID: 24253521
CONCLUSION: PXDNL is a unique component of the heart with a recently evolved inactivation of peroxidase function. The elevation of PXDNL levels in the failing heart may contribute to ECM dysregulation due to its antagonism of PXDN function....
CONCLUSION: PXDNL is a unique component of the heart with a recently evolved inactivation of peroxidase function. The elevation of PX …
Human gene expression microarray analysis of the HPV 6bE7-HaCaT stable cell line.
Zhang B, Chen X, Zhou Q, Song Y, Sun S, Cheng H. Zhang B, et al. Gene. 2018 May 30;657:60-68. doi: 10.1016/j.gene.2018.02.067. Epub 2018 Mar 2. Gene. 2018. PMID: 29501815
The most significantly enhanced genes HPV 6bE7-HaCaT cells were SIMC1, S100A8 and S100A9, whereas PXDN expression was markedly down-regulated. GO analysis showed that HPV 6bE7 primarily affected biological processes and that the most significant difference was in heart …
The most significantly enhanced genes HPV 6bE7-HaCaT cells were SIMC1, S100A8 and S100A9, whereas PXDN expression was markedly down-r …
Identification and characterization of VPO1, a new animal heme-containing peroxidase.
Cheng G, Salerno JC, Cao Z, Pagano PJ, Lambeth JD. Cheng G, et al. Free Radic Biol Med. 2008 Dec 15;45(12):1682-94. doi: 10.1016/j.freeradbiomed.2008.09.009. Epub 2008 Sep 23. Free Radic Biol Med. 2008. PMID: 18929642 Free PMC article.
One, termed VPO1 for vascular peroxidase 1, exhibits its highest tissue expression in heart and vascular wall. A second, VPO2, present in humans but not in mice, is 63% identical to VPO1 and is highly expressed in heart. ...The absorbance spectra of VPO1 are similar …
One, termed VPO1 for vascular peroxidase 1, exhibits its highest tissue expression in heart and vascular wall. A second, VPO2, presen …
Vascular peroxidase 1 is a novel regulator of cardiac fibrosis after myocardial infarction.
Liu Z, Xu Q, Yang Q, Cao J, Wu C, Peng H, Zhang X, Chen J, Cheng G, Wu Y, Shi R, Zhang G. Liu Z, et al. Redox Biol. 2019 Apr;22:101151. doi: 10.1016/j.redox.2019.101151. Epub 2019 Feb 27. Redox Biol. 2019. PMID: 30844643 Free PMC article.
The results showed that VPO1 expression was robustly upregulated in the failing human heart with ischemic cardiomyopathy and in a murine model of MI accompanied by severe cardiac fibrosis. ...
The results showed that VPO1 expression was robustly upregulated in the failing human heart with ischemic cardiomyopathy and in a mur …
Acute physical activity effects on cardiac gene expression.
Simonsen ML, Alessio HM, White P, Newsom DL, Hagerman AE. Simonsen ML, et al. Exp Physiol. 2010 Nov;95(11):1071-80. doi: 10.1113/expphysiol.2010.054858. Epub 2010 Aug 9. Exp Physiol. 2010. PMID: 20696783 Free PMC article.

A relatively small percentage of genes (1.9%) were differentially expressed (P < 0.05) following acute swimming activity in all groups, but only 37 unique and identifiable genes reached or exceeded twofold differences in expression. The genes Atf3, Fos, Apold1 and Pxdn

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A relatively small percentage of genes (1.9%) were differentially expressed (P < 0.05) following acute swimming activity in all groups, b

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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, 'an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A; CHARGE Neurology Working Group; Chauhan G, Christensen K, Cocca M; COGENT-Kidney Consortium; Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Ev… See abstract for full author list ➔ Sung YJ, et al. Am J Hum Genet. 2018 Mar 1;102(3):375-400. doi: 10.1016/j.ajhg.2018.01.015. Epub 2018 Feb 15. Am J Hum Genet. 2018. PMID: 29455858 Free PMC article.
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architec …
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary …
11 results